publications | Nourhan E. H. Abdelfattah

2026

Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma

Nourhan Abdelfattah, S. Natarajan, H. N. Tran, and 14 more authors

Cancer Cell, 2026

@article{abdelfattah2026yap1,
  title = {Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma},
  author = {Abdelfattah, Nourhan and Natarajan, S. and Tran, H. N. and Wong, T. and Faisal, M. and Maldonado, J. and McMinimy, R. and Borland, H. and Chen, S. H. and Zhao, H. and Vasquez, M. and Rodriguez, F. F. and Wagner, C. R. and Camargo, F. and Olson, J. and George, Joshy and Yun, Kyuson},
  journal = {Cancer Cell},
  volume = {44},
  number = {4},
  pages = {760--776.e8},
  year = {2026},
  doi = {10.1016/j.ccell.2026.01.005},
}

Combined inhibition of S100A4 and TIGIT suppresses late-stage breast cancer metastasis

J. S. Leu, H. Deng, H. N. Tran, and 3 more authors

Cancer Letters, 2026
A prognostic matrix code defines functional glioblastoma phenotypes and niches

M. Vishnoi, Z. Dereli, Z. Yin, and 10 more authors

Communications Biology, 2026

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Deciphering myeloid cell diversity in human cancer: insights from a comprehensive pan-cancer single-cell analysis

Nourhan Abdelfattah

Manuscript in preparation, 2026
Sex-specific neuroinflammatory programs in Alzheimer’s disease revealed by single-nucleus RNA-seq

Nourhan Abdelfattah

Manuscript in preparation, 2026

2025

Phase I/II trial of encorafenib, cetuximab, and nivolumab in microsatellite stable, BRAFV600E metastatic colorectal cancer

V. K. Morris, C. M. Parseghian, V. Bahrambeigi, and 2 more authors

Cancer Cell. ^*Co-first author , 2025

DOI Bib HTML

@article{morris2025crc,
  title = {Phase I/II trial of encorafenib, cetuximab, and nivolumab in microsatellite stable, BRAFV600E metastatic colorectal cancer},
  author = {Morris, V. K. and Parseghian, C. M. and Bahrambeigi, V. and Abdelfattah, Nourhan and others},
  journal = {Cancer Cell},
  volume = {43},
  pages = {2106--2118.e3},
  year = {2025},
  doi = {10.1016/j.ccell.2025.08.002},
}

Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory

S. Timilsina, J. Y. Huang, Nourhan Abdelfattah, and 1 more author

Nature Communications. ^*Co-first author , 2025

DOI Bib HTML

@article{timilsina2025foxm1,
  title = {Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory},
  author = {Timilsina, S. and Huang, J. Y. and Abdelfattah, Nourhan and others},
  journal = {Nature Communications},
  volume = {16},
  pages = {3967},
  year = {2025},
  doi = {10.1038/s41467-025-59186-3},
}

Rictor CRISPR gene editing by lipid nanoparticle delivery stimulates anti-tumor immunity in breast cancer liver metastasis model

Y. Ali, T. Galbraith, Nourhan Abdelfattah, and 12 more authors

bioRxiv. Under revision at ACS Nano , 2025

DOI Bib HTML

@article{ali2025rictor,
  title = {Rictor CRISPR gene editing by lipid nanoparticle delivery stimulates anti-tumor immunity in breast cancer liver metastasis model},
  author = {Ali, Y. and Galbraith, T. and Abdelfattah, Nourhan and Ziemys, A. and Wong, T. L. and Hashimoto, C. and Faisal, M. and Qian, X. and Cook, H. and Pandita, T. and Xu, Y. and Rosato, R. and Chen, S. H. and Yun, Kyuson and Leonard, F.},
  journal = {bioRxiv},
  year = {2025},
  doi = {10.1101/2025.06.26.661471},
}

scSidekick: reproducible, interpretable, and teachable single-cell and spatial transcriptomics analysis

Nourhan Abdelfattah

. Application note submitted to Bioinformatics; MIT license , 2025

DOI Bib HTML

@misc{scsidekick2025,
  title = {scSidekick: reproducible, interpretable, and teachable single-cell and spatial transcriptomics analysis},
  author = {Abdelfattah, Nourhan},
  year = {2025},
  doi = {10.5281/zenodo.21285418},
}

2024

Nuclear respiratory factor-1 induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells

H. Lee, M. Massaro, Nourhan Abdelfattah, and 4 more authors

Aging Cell, 2024

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2022

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target

Nourhan Abdelfattah, Parveen Kumar, Caiyi Wang, and 17 more authors

Nature Communications. ^*Co-first author , 2022

DOI Bib HTML

@article{abdelfattah2022s100a4,
  title = {Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target},
  author = {Abdelfattah, Nourhan and Kumar, Parveen and Wang, Caiyi and Leu, Jia-Shiun and Flynn, William F. and Gao, Ruli and Baskin, David S. and Pichumani, Kumar and Ijare, Omkar B. and Wood, Stephanie L. and Powell, Suzanne Z. and Haviland, David L. and Parker Kerrigan, Brittany C. and Lang, Frederick F. and Prabhu, Sujit S. and Huntoon, Kristin M. and Jiang, Wen and Kim, Betty Y. S. and George, Joshy and Yun, Kyuson},
  journal = {Nature Communications},
  volume = {13},
  pages = {767},
  year = {2022},
  doi = {10.1038/s41467-022-28372-y},
}

Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors

Joshy George, Y. Chen, Nourhan Abdelfattah, and 9 more authors

Cancer Research Communications. ^*Co-first author , 2022

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M6A RNA methylation regulates histone ubiquitination to support cancer growth and progression

P. Yadav, S. Panneerdoss, S. Rajamanickam, and 12 more authors

Cancer Research, 2022

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The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events

S. Timilsina, S. Rajamanickam, A. D. Rao, and 4 more authors

Cancer Letters, 2022

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Targeting aberrant replication and DNA repair events for treating breast cancers

S. Rajamanickam, J. H. Park, P. Subbarayalu, and 10 more authors

Communications Biology, 2022

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2019

MicroRNA 584-5p compositions and methods for treating cancer

Nourhan Abdelfattah, and Manjeet K. Rao

International Patent Application PCT/US19/28497; US Patent Application 17/049,836 , 2019

2018

MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

Nourhan Abdelfattah, S. Rajamanickam, S. Panneerdoss, and 7 more authors

Nature Communications, 2018

DOI Bib HTML

@article{abdelfattah2018mir584,
  title = {MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma},
  author = {Abdelfattah, Nourhan and Rajamanickam, S. and Panneerdoss, S. and Timilsina, S. and Onyeagucha, B. C. and Garcia, M. and Chen, Y. and Brenner, A. and Houghton, P. and Rao, Manjeet K.},
  journal = {Nature Communications},
  volume = {9},
  pages = {4541},
  year = {2018},
  doi = {10.1038/s41467-018-06808-8},
}

Cross-talk among writer, reader and eraser of m6A regulates cancer growth and progression

S. Panneerdoss, V. Eedunuri, S. Timilsina, and 5 more authors

Science Advances, 2018

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2017

Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis of apoptotic germ cells

S. Panneerdoss, V. Suryavathi, Nourhan Abdelfattah, and 8 more authors

Nature Communications, 2017

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Novel post-transcriptional and post-translational regulation of pro-apoptotic protein BOK and anti-apoptotic protein Mcl-1 determine fate of breast cancer cells to survive or die

B. Onyeagucha, P. Subbarayalu, Nourhan Abdelfattah, and 10 more authors

Oncotarget, 2017

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